Erythropoietic protoporphyria is a genetic disease in which ferrochelatase is defective. Protoporphyrin accumulates in erythrocytes, leaks into the plasma and results in severe skin photosensitivity.

Study identifies chlorcyclizine as a potential treatment to reduce protoporphyrin-IX accumulation ... EPP results from reduced ferrochelatase activity, causing PP-IX accumulation in the liver ...