Newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus. The classic estrogen receptor signaling pathway occurs ...

Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets ...

When the atrial natriuretic hormone binds to GC-A, the receptor is activated and sends a signal to the interior of the cell where several pathways work to lower blood pressure. This activation can ...

Elena Shagisultanova, MD, PhD, is working to uncover effective treatments for HER2-positive breast cancer patients by combining different drugs to counteract the cancer cells’ proliferation.

In 2021, a research team discovered the insulin-inhibitory receptor 'Inceptor' and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another ...

"But although we know the individual nerve signaling pathways that control each of these urinary tract components, we don't ...

(ESR1+) in Barrington's nucleus as key regulators coordinating both bladder contraction and the relaxation of the external urethral sphincter. Using appropriate and validated methodologies aligned ...

In cellular biology, hormones are fundamental to signaling processes that influence cellular behavior ... Testosterone, noted for its anti-inflammatory properties, interacts through diverse pathways, ...

The study identifies the adhesion G-protein-coupled receptor A3 (ADGRA3) as a potential target for activating adaptive ... hesperetin in inducing the development of beige adipocytes through the ...