The CT26 cell lines that stably express CD95L, CD95L cleavage mutant or CD95L-binding mutant were generated. Briefly, human CD95L cDNA, its cleavage mutant cDNA or its binding mutant cDNA were ...

Nature Research Intelligence gives you a greater focus on real-world impact, enabling you to find the most effective strategies and collaborations to deliver maximum benefit from your research ...

Feb. 26, 2025 — It's not what you do, it's how readily you do it. Rapid evolutionary change might have more to do with how easily a key innovation can be gained or lost rather than with the ...

Bone marrow in the skull plays a surprisingly important role in ageing ...

We can anticipate many false claims as we approach the U.S. presidential election—including untrue allegations of mass voting by noncitizens or of “suspicious vans” outside polling booths ...

Experience the unforgettable moment when Sir David encounters Lonesome George, the last of his kind.

Traditionally, due to the development costs and exotic nature, mid-engined cars are expensive ... lb-ft of torque at 3,200 rpm. Toyota used a CT26 single turbocharger and electronic fuel injection ...

The severe side effects of systemic chemotherapy for cervical cancer encourage the use of topical intravaginal drug delivery systems. 5-fluorouracil, 5-FU, is an anticancer drug accepted in clinical ...

Checkpoint immunotherapy that targets inhibitory receptors of T cells, thereby reversing the functional exhaustion of T cells, marks a breakthrough in anticancer therapy. The success of T ...

Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and ...

点击蓝字关注我们【导读】肿瘤相关中性粒细胞（TANs）在肿瘤微环境（TME）中积极与抗体药物共轭物（ADCs）相互作用，但它们对ADC治疗反应的详细机制仍有待全面阐明。在这项研究中，团队探讨了ICAM1靶向ADC如何影响宫颈癌临床前模型中的TAN动态 ...

(23) When tested in vivo using a mouse colon carcinoma CT26 syngeneic tumor model, we observed prolonged tumor exposure of the released TLR7 agonist with the TLR7 agonist–antibody conjugate compared ...