AI-assisted AAV capsid engineering has transformative potential in terms of accelerating and optimizing the development of gene therapies.

In 2014, researchers combined DNA barcoding with next-generation sequencing (NGS) to develop the adeno-associated virus (AAV) barcode-seq technology for streamlining AAV screening. Using this method .

Starting with parental AAV serotypes, the biotech generates diverse libraries of tens of millions of highly manufacturable capsids. Through successive rounds of screening in adult old-world NHPs ...

Somatic gene transfer with vectors such as adeno-associated virus (AAV) can overcome these limitations. ReGenX's AAV Vector Technology gives extremely efficient and stable gene expression in ...

In their AAV screening experiments, which typically involved a mixture of different AAV ... 2 To do this, his team designed an AAV library composed of 25 recombinant AAV serotype 2 (AAV2) viral clones ...