They had already identified sequences in the pre-mRNA in the EDA neighborhood necessary ... transcription, and RNA processing across different cells and tissues. In addition, scientists are ...

Transcriptome-wide measurement of subcellular mRNA dynamics in mouse ES cells reveals that nuclear retention is the ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions. Imogen is a PhD student in the Division of Structural ...

The pre-mRNA molecule thus goes through a modification process in the nucleus called splicing during which the noncoding introns are cut out and only the coding exons remain. Splicing produces a ...

In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps ...