After pre-mRNA processing, mRNPs would interact with NPCs, perhaps through Mex67 and Mtr2 (TAP and p15). The Yra1-Mex67 interaction may be crucial for this. If additional studies confirm that Yra1 ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions. Imogen is a PhD student in the Division of Structural ...

In total, these results indicate that inhibition or slowing of canonical pre-mRNA processing events shifts the steady-state output of protein-coding genes towards circular RNAs, which likely helps ...