The search for the elixir of eternal youth has fascinated humanity for centuries. In recent times, a compound called ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

雷帕霉素靶蛋白（mTOR）是一种在哺乳动物细胞中起着关键作用的蛋白激酶，参与细胞生长、增殖和存活等过程，同时也在脑胶质瘤的发生发展中发挥重要作用。然而mTOR激酶抑制剂的选择性差导致了较高的毒性和较差的临床安全性，同时耐药性问题进一步削弱了其临床疗效。这些因素极大地限制了mTOR抑制剂的临床应用，至今尚未有除雷帕霉素之外的mTOR抑制剂获批上市。

The mTOR complex 1 (mechanistic Target of Rapamycin complex 1, in short ‘mTORC1’) is the central component of a protein network that senses whether a cell has access to sufficient nutrients. Therefore ...

Groundbreaking studies in mice have sparked a frenzy among longevity enthusiasts—but human trials are still in their infancy.

Researchers suggest findings represent "a major advancement in developing microbiota-based intervention strategies to improve child health." ...

Gut microbiome composition during pregnancy has long-term effects on offspring stem cell growth and development, researchers ...

In an eagerly awaited study, Memorial Sloan Kettering researchers report on the molecular structure of mTOR, a protein commonly mutated in cancer. Structural Biology Program Chair Nikola P. Pavletich ...

BCAA supplements that contain concentrated amounts of amino acids are popular with gym goers. We take a look at how exactly ...

Am J Health Syst Pharm. 2010;67(24):2095-2106. The second mTOR complex, mTORC2, contains mTOR, mLST8, and several unique proteins, including rictor (rapamycin-insensitive companion of mTOR).