PLP associates with raft-type microdomains, whereas epidermal growth factor receptor (EGFR; which is sorted into ILVs that are trafficked to lysosomes) colocalizes with the ubiquitin-binding ...

These synthetic proteins harness the lysosomal machinery to degrade disease-related proteins. As a proof of concept, they targeted EGFR, a protein often overexpressed in cancers, achieving an 85% ...