A phase 1/2 clinical trial is ongoing in patients with HER2 ... antibody candidates in preclinical development, including MCLA-158, which targets the Wnt signaling pathway receptor LGR5 and EGFR.

EGF receptor (EGFR) and HER2 are two members of the ... a humanized monoclonal antibody against the HER2 extracellular domain, allowed an improvement in patients' survival either in advanced ...

Explore the challenges and advancements in anti-EGFR antibody treatment for metastatic colorectal cancer. Discover how ...

Antibody-drug conjugates (ADCs ... showing potential in treating HER2-expressing cancers. M1231, which targets MUC1 and EGFR, ...

The anti-HER2 biparatopic antibody (bpAb) KJ-015 was rationally designed at Shanghai Bao Pharmaceuticals Co. Ltd. by leveraging published antibody-antigen structures to share common light chain with ...