WNT 信号的调控机制 ：研究发现 KPN 肿瘤类器官的 WNT 通路激活不依赖于配体 - 受体相互作用，而是依赖 TNKS 活性和 CDX2 表达。CDX2 下调会导致 WNT 通路活性增加，TNKS 抑制则会降低 WNT 通路活性。同时，KPN 肿瘤类器官存在细胞状态的异质性，包含高 WNT 活性和高 YAP 活性的细胞群体。

本文全面综述了 Wnt 信号通路在癌症中的作用。Wnt 信号通路对肿瘤发生、发展和转移意义重大（如在结直肠癌 中）。文中介绍了相关生物标志物（如 APC、β-catenin 等），探讨了靶向治疗策略及面临的挑战，为癌症个性化治疗提供了重要参考。 ### Wnt 信号通路在 ...

Figure 2: Human APC and CTNNB1 mutations are associated with carcinogenesis. Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so ...

Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...

Examination of the tumour suppressor adenomatous polyposis coli (APC) has shown that it may be multifunctional. Recent work has demonstrated dynamic interactions of APC with the microtubule ...

driven by Wnt signaling through LRP5/6 and β-catenin, which interact with APC, CKIα, and TCF/LEF. The NF-κB pathway is a central signaling network regulating inflammation, immune responses ...