Instead, it depends largely on materials synthesized in the nerve cell body and delivered by axonal transport. Wallerian degeneration is not, however, merely deprivation of axonally transported ...

The stereotypical pattern of events known as Wallerian degeneration that occurs in axons in response to various physical and chemical insults is thought to be driven by a common signalling pathway ...

This disruption leads to axonal dystrophy and degeneration, ultimately resulting in severe neurological impairments." To carry out their experiments, Bonifacino and his collaborators leveraged the ...

A key to their investigation was to elucidate the critical involvement of microglia in axonal degeneration post-spinal cord axon injury. Microglia are primary immune cells in the central nervous ...