Since the application of molecular biology in cancer biology, lung cancer research has classically focused on molecular drivers of disease. One such pathway, the hypoxic response pathway, is ...

Introduction: Tumor tissues exhibit significantly lower oxygen partial pressure compared to normal tissues, leading to hypoxia in the tumor microenvironment and result in resistance to tumor ...

However, the available data based on the recruitment of circulating cells to the tumor microenvironment has been so far carried out by conventional co-culture systems which ignore the hypoxic gradient ...

Background Scirrhous hepatocellular carcinoma (SHCC) is one of the unique subtypes of hepatocellular carcinoma (HCC), characterized by abundant fibrous stroma in the tumor microenvironment. However, ...

The cancer microenvironment, or tumour microenvironment ... discuss how intratumoural hypoxia is a driving force in tumour evolution, alongside driver gene mutations, through the generation ...

de la Calle-Fabregat, C., et al. (2024) NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the ...

The present study aimed to develop an ex vivo model that could mimic the pre-metastatic tumor microenvironment, incorporating ...

The determinative characteristic of cancer cells, something normal cells lack, is their ability to survive even in a hypoxic microenvironment, where the level of oxygen normally required by living ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

Department of Mechanical Engineering, Seoul National University, Seoul, Republic of Korea Institute of Advanced Machines and Design, Seoul National University, Seoul, Republic of Korea Cancer ...

we are studying the tumor microenvironment to understand the role of hypoxia, tumor vascularization, macromolecular transport and tumor metabolism in tumor progression, metastasis and ascites ...