Tooth Fairy was followed up by a sequel, starring Larry the Cable Guy as the title character. Directed by Alex Zamm, Tooth Fairy 2 had a direct-to-video release on March 6, 2012.

Derek Thompson (Dwayne "The Rock" Johnson) is "The Tooth Fairy", a hard-charging minor league hockey player whose nickname comes from his habit of separating opposing players from their bicuspids.

An adventurous teenage tooth fairy teams up with the world's cutest troll and a daring goblin girl to rescue their kingdom from evil, encroaching spiders." ...

Meanwhile, in fairy world, Violetta is unable to pass the tooth fairy examination and decides to take matters into her own hands in order to prove her worth. She steals a gem from a pompous fairy ...