Histological examination of kidney biopsies revealed pathology similar to that found in the mice, with the capillary thrombosis that clinicians refer to as thrombotic microangiopathy. These signs ...
suggest that chronic eculizumab therapy might provide meaningful clinical benefit as measured by the resolution of thrombotic microangiopathy. Our own experience has also been encouraging ...
Risk for thrombotic microangiopathy (including hemolytic uremic syndrome and thrombotic thrombocytopenic purpura) esp. in those with severe infections, GVHD, HLA mismatch. Elderly. Labor & delivery.