Of the questions concerning diuretic therapy: class effect, mechanism of action, and additivity with other medication classes are noteworthy issues. The manner in which thiazide-type diuretics ...

Under these circumstances, BP control may be restored by the addition of a diuretic. In turn, patients having been successfully treated with diuretics can occasionally see BP control lapse because ...

Thiazide diuretics reduce the renal excretion of calcium and have been used to treat calcium nephrolithiasis with hypercalciuria; however, concerns remain over the long-term efficacy and adverse ...

Following reports linking thiazide diuretics with increased biliary cholesterol saturation, it has been postulated that these drugs increase the risk of gallstone development. Leitzmann and ...

Death risk doubled for patients experiencing early hyponatremia after starting a thiazide diuretic. Patients who experience hyponatremia soon after starting thiazide diuretics have an increased ...