This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

为解决镉（Cd）导致的睾丸毒性问题，研究人员开展了关于植物乳杆菌（L. plantarum）对 Cd 诱导睾丸毒性影响的研究。结果发现，L. plantarum 可减轻 Cd 诱导的炎症相关基因表达上升，缓解睾丸毒性。该研究为对抗 Cd 等重金属毒性提供了新方向。

结果显示，在 TNF-α 刺激的 FLSs 和 RA 大鼠滑膜组织中，Roquin-1 的 mRNA 和蛋白质表达显著降低。Roquin-1 与 Regnase-1 相互作用，促进 FGF2 降解，进而抑制 TNF-α 刺激的 FLSs 的增殖、迁移和炎症反应。研究还表明，Roquin-1 与 Regnase-1 相互作用，通过抑制 FGF2 表达来抑制 TNF ...

Tumor necrosis factor-α (TNF-α) mRNA served as the target gene and is known to be substantially upregulated in macrophages in response to inflammatory agents like lipopolysaccharide (LPS ...

Both need to be associated with (A+U)-rich elements in the 3′ untranslated region (UTR) of the TNF alpha mRNA. Now the researchers introduce a miRNA as the mediator of this interaction.

The cytokines considered most relevant to the pathogenesis of HF are tumor necrosis factor-a (TNF) and interleukin(IL)-6, and they have been the most extensively studied in this disorder.

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.

Vaccine skeptics have long-since leveraged the rapid roll out of mRNA vaccines to add fuel to heated arguments surrounding vaccine safety. As a result, a growing share of the public is wary of ...

Officials at the National Institutes of Health (NIH) have reportedly told scientists to scrub all references to mRNA vaccine technology from grant applications, sparking fears that the agency ...