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非致病性人类同种抗体阻断 TCR 与 HLA-A11:01 的结合:移植免疫新突破
为了更深入地了解 1H5 抗体的作用机制,研究人员构建了表达特定 TCR 的 T 细胞系。他们设计了一种重组慢病毒构建 ... 通路中的细胞外信号调节激酶(ERK)起着关键作用。研究人员利用成像流式细胞术发现,1H5 抗体能够明显抑制 NFAT 的核转位以及 pERK 向细胞核 ...
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