为解决染色质重塑酶利用 Snf2 型 ATP 酶移动核小体 DNA 机制不明的问题，研究人员开展了对人类染色质重塑酶 SNF2H（ISWI 家族成员）的研究。通过冷冻电镜观察，得出 SNF2H 重塑染色质的动态过程及关键步骤，该研究成果有助于理解 ATP 依赖的染色质重塑机制127。

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can ...

Research published in Cell Research from Mario Halic, PhD, St. Jude Department of Structural Biology, revealed 13 distinct ...

Scientists at St. Jude Children’s Research Hospital used a series of cryo-EM structures to visualize dynamics pivotal to ...

April 3, 2025) Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this ...