The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy ...

Proteins have four levels of structure: primary (amino acid sequence), secondary (local folding patterns like alpha helices and beta sheets), tertiary (overall 3D shape), and quaternary (assembly of ...

“Protein structure can change in the culture condition ... Unveiling them will show the pathway for developing new, targeted drugs. Toshifumi Takao, a protein chemist at the Institute ...

These insights could drive the development of new drugs to treat transthyretin amyloidosis, a progressive and fatal disease.

Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical ...

Here we show that we can actually start with a gigantic, native protein complex and go all the way down to characterization of its primary structure and find minor protein sequence perturbations ...