In this GTP-bound, active, state ... Other members of the Ras superfamily, such as Rho, Rab and Ran proteins, are regulated by similar interactions with nucleotides. However, they interact ...

The Rho family of small GTPases has attracted considerable research interest over the past 5 years. During this time, we have witnessed a remarkable increase in our knowledge of the biochemistry ...

Rho GTPases are molecular switches that switch between an active and an inactive state by binding to the phosphate compounds GTP and GDP. GTP corresponds to the 'on' position of the switch and ...