Drug leads identified on the basis of subsite ... Box 3 | The generation of renin inhibitors — a classic protease inhibitor campaign Renin cleaves angiotensinogen to form angiotensin I and ...

The effects of SGLT2 inhibitors on the kidney to prevent progression of chronic kidney disease, congestive heart failure, ...

Hypertension (high blood pressure) affects an estimated 1 billion people worldwide and approximately 65 million people in the US alone. If not treated effectively, this common disorder can lead to ...

Angiotensin II (AT-II)-Receptor Antagonists are Reviewed. Research focused on blocking the renin- angiotensin system (RAS) led to the discovery of angiotensin-converting-enzyme (ACE) inhibitors ...

Scientists have discovered that long-term use of common medications for high blood pressure and heart failure could contribute to kidney damage. While these drugs, including ACE inhibitors, are ...

Now that they know the cause, researchers say the next step is to figure out how to use the effective blood pressure drugs known as renin-angiotensin system inhibitors—often called RAS ...

Teams of researchers are investigating empagliflozin and dapagliflozin in patients with autosomal dominant polycystic kidney disease (AD PKD).

If the clinical history is not helpful (e.g., there is no documentation of the efficacy of drug "A ... a reactive renin system should have an increased renin while on ACE inhibitor therapy.