此外，对于阿尔茨海默病、亨廷顿舞蹈症等神经系统疾病患者来说，当针对他们的核斑点加以研究，就能发现其与正常人在 RNA 剪接和核斑点定位上的差异，从而助力于通过干预 RNA 剪接来治疗神经疾病。 同时，ARTR-seq ...

文章来源：丁萌萌,韩佳轩,孟心语,等.解码细胞隐藏的生命调节信息——微小 RNA 的研究进展[J]. 生物学通报, 2024, 59(11): 1-7.编者按为了更好地满足读者对优秀期刊文章的需求，本刊微信公众号择优推送当期文章，持续推送，敬请关注!本刊2024年第11期刊发的《解码细胞隐藏的生命调节信息——微小 RNA ...

Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...

One possible explanation is that effective targeting requires the binding site to be highly dynamic. Although it is unlikely that the protein–RNA complex disassembles at any point during the ...

RNAs have been shown to have a function in protein secretion after thousands more binding targets were identified using a ...

The study significantly expands our understanding of these proteins’ functions and establishes them as a new class of RNA-binding proteins. C2H2 zinc finger proteins are the largest group of DNA ...

ABOVE: Hematopoietic stem cells have mechanisms in place to generate intrinsically disordered proteins, which could underlie ...

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published in Nature ...

Their study, published in Nature Cell Biology, shows that a protein called Serrate connects RNA modification and microRNA production, two essential cellular functions, in a way previously unknown.

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence ...

Patients with an overproduction of protein from the chromodomain helicase DNA binding (CHD2 ... of MIT and Harvard have ...