The study of protein–protein interactions that involve integral membrane proteins has been thwarted by the difficulty of biochemical approaches and the unsuitability of genetic two-hybrid ...

Membrane proteins are proteins found in cell membranes, either at the surface or on intracellular organelles. Integral membrane proteins such as receptors and ion channels span the membrane.

The research focus of Kaspar Locher and his group is the structural and mechanistic investigation of integral membrane proteins facilitating active transport processes or membrane-associated ...