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PLK1 介导 PDCD4 磷酸化促进前列腺癌恩杂鲁胺耐药的机制及联合治疗策略
为探究恩杂鲁胺(enzalutamide)耐药机制,研究人员开展相关研究,发现 PLK1 磷酸化 PDCD4 致其降解,联合治疗或可克服耐药。 前列腺癌是全球男性癌症相关死亡的主要原因之一,雄激素受体(AR)信号在其发展和进展中起着关键作用。对于晚期前列腺癌患者 ...
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