Figure 2: Classification of the poly-ADP-ribose-polymerase (PARP) family according to the structural ... of variable length and with a branched, complex structure, the mono-ADP-ribosylation ...

The PARP protein family comprises 17 members, but PARP1 and PARP2 are the main proteins involved in DNA repair. Both proteins regulate the DDR network, but PARP1 also regulates transcription and ...