The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Gene set enrichment analysis (GSEA) showed that WNT signaling, cell cycle, p53, and apoptotic pathways were enriched in the high-IARS2 expression group of TCGA-PAAD. The gene expression-based ...