Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

为探究衰老细胞中基因组不稳定与炎症的关联，研究人员聚焦 p53，发现其可抑制 CCF 积累及炎症，或为衰老相关疾病治疗提供新靶点。 在生命的长河中，衰老就像一个无法避免的 “关卡”，它带来了身体机能的衰退，还让我们更容易患上各种疾病。随着年龄的 ...

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% ...

Around this time, cancer researchers across different disciplines concluded that the gene encoding p53 was an oncogene. Once they started searching, scientists found p53 in almost every cancer type.

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

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Stressed mitochondria can cause senescent cells to form CCF and dampen the expression of the gene carrying the blueprint for p53. “Altogether, we’ve identified a cellular circuit capable of ...

Sánchez-Rivera and his team found that certain mutations cause phenotypes that differ from those observed previously in overexpression model systems, particularly those affecting the oligomerization ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...