和p38丝裂原活化蛋白激酶（p38 MAPK）通路，显著诱导白血病细胞凋亡。该研究为靶向鞘脂代谢的抗癌药物开发提供新思路，发表于《Molecular Cancer》。 白血病作为造血系统的恶性疾病，传统化疗存在耐药性强、副作用大等局限。鞘脂代谢通路中的神经酰胺（ceramide ...

One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.

研究人员探究 GDF 11 对 BV 2 小胶质细胞的影响，发现其经 p38 MAPK 通路调控细胞，有潜在治疗意义。

A biotech company advancing next-generation targeted protein degradation (TPD) therapies for intractable diseases.

The anti-melanogenesis effect of ligustroside derived from Ligustrum japonicum and its underlying mechanisms are explored.