The new understanding provided by the RANK/RANKL/OPG paradigm for both differentiation and activation of osteoclasts has had tremendous impact on the field of bone biology and has opened new ...

OPG and RANKL Are Regulated by Systemic Hormones ... stromal cells interacting with receptors on hematopoietic osteoclast precursor cells. RANK-L: receptor activator of NF-kappaB ligand; RANK ...

OPG is a cytokine that plays a significant role in bone remodeling by inhibiting the formation of osteoclasts, the cells responsible for bone resorption. Understanding how genetic variations ...