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18 天
N - 乙酰半胱氨酸(NAC)缓解氯胺酮诱导发育神经毒性的机制探究
研究人员利用 SD 大鼠、PC 12 细胞和 HAPI 细胞,探究 NAC 缓解氯胺酮神经毒性机制,发现其可抑制 ROS 相关通路。 氯胺酮是一种 N - 甲基 - D - 天冬氨酸(N-methyl-D-aspartate,NMDA)受体拮抗剂,具有麻醉和镇痛特性,被广泛用于小儿围手术期麻醉的诱导和维持。
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