研究针对 MYCN 扩增型神经母细胞瘤治疗难题，探究 FAM13A 与 N-Myc 作用，发现 FAM13A 或为潜在治疗靶点。 研究背景：攻克难题，探索新靶点 神经母细胞瘤（Neuroblastoma，NB）是一种常见于婴幼儿时期的神经内分泌肿瘤，起源于神经嵴细胞。它在儿童癌症相关死亡中占 ...

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is ...

Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...

This second interaction between N-Myc and Aurora-A is particularly important. That's because mis-regulation of Myc proteins is a hallmark of cancer and N-Myc plays a key role in childhood brain ...