Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding ...

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking ...

多发性硬化症（MS）发病机制不明，炎症性小胶质细胞活动贯穿病程。研究人员围绕小胶质细胞中干扰素调节因子 5（IRF5）展开研究。结果发现 IRF5 对髓鞘降解和胆固醇稳态至关重要，或可成为治疗 MS 的潜在靶点，为相关治疗提供新思路。

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Now, two independent studies have honed in on inflammatory microglia as a potential therapeutic strategy. In mice, induction of T regulatory (T reg) cells or supplementation with a metabolic ...

Researchers from Charité - Universitätsmedizin Berlin and the Max Delbrück Center have identified the precise mechanism by ...

VG-3927 showed a predictable and dose-dependent pharmacokinetic (PK) profile that supports once-daily dosing. These data demonstrated that VG-3927 has high CNS penetrance with an estimated cerebral ...

A new study reveals that inflammation during pregnancy may impair neurodevelopment in infants by reducing CD11c-positive ...

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

Age-related neurodegenerative disorders — motor neuron diseases, demyelinating diseases, Alzheimer’s disease, and other ...