People with acid reflux often rely on acid-reducing medications to ease symptoms. Depending on the severity of your symptoms, ...

Proton pump inhibitors (PPIs) are a class of very effective and generally safe medicines used to treat heartburn, gastroesophageal reflux disease (GERD), and gastric ulcers.But not everyone who ...

PPIs are widely prescribed for acid suppression and are generally well tolerated; however, several case reports and a case series have indicated that PPIs have a causal role in the development of ...

The study objective was to evaluate the association of proton pump inhibitors (PPIs) and community-acquired pneumonia (CAP). The design was a meta-analysis of nine case–controlled and cohort ...

Omeprazole, the prototype drug of PPIs, is metabolized primarily by CYP2C19 to 5-hydroxyomeprazole. 5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole ...

This means the medicine doesn't work as well after the body gets used to it, and higher doses may be necessary to get the same results. Deciding how long to use PPIs can be a tricky situation.

A growing body of evidence links use of proton pump inhibitors to kidney problems, including kidney failure in patients with existing CKD.

A recent study published in the December issue of the Journal of Gastroenterology and Hepatology highlights Vonoprazan's ...

Public and patient involvement (PPI) in clinical research is the new normal, but bridging the gap between how industry and charities work isn’t always easy. A new guidance document is here to help.

CURE has been associated with the members of The Sheffield Emergency Care Forum (SECF) for many years working on studies within Emergency Medicine. SECF is an independent group representing ...