Injury-induced edema, hyperemia, and hemorrhage disrupt this balance, causing ICH. ICH, in turn, reduces cerebral blood flow ... are less effective than mannitol at lowering ICP and have unproven ...

Intravenous mannitol and hypertonic saline lead to ... leading to decreased edema, relative brain dehydration and decreased ICP. Pentobarbital therapy has been associated with improved ICP ...