为解决结直肠癌（CRC）长期生存率低且长链非编码 RNA（lncRNA）在其发展中功能不明的问题，研究人员开展关于 lncRNA 01730 与 MYC、Wnt/β-catenin 通路关系的研究。结果发现 lncRNA 01730 在 CRC 组织中高表达，或可作预后新指标，为治疗提供方向。 结直肠癌（CRC ...

这项颠覆性发现不仅解开了PDAC进化之谜，更为抗癌战争打开新维度：研究人员已发现用BRD4抑制剂瓦解ecDNA转录枢纽，使耐药肿瘤存活率直降58%。当我们凝视ecDNA时，看到的不仅是生命的脆弱，更是自然进化赋予癌细胞的惊人智慧——而我们，正站在解码这种智慧、重写抗癌规则的历史转折点。

“We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT,” explained Antonia Malinova, PhD, co-first author and a former PhD student at the University ...

“We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT”, explains Antonia Malinova, co-first author and a former PhD student at the University of Verona.

"We found that organoids bearing MYC on extrachromosomal DNA could shift their dependency on WNT," explains Antonia Malinova, ...