Yale University researchers have identified a molecular mechanism driving the structural abnormalities leading to lissencephaly that have, until recently, been elusive. Further, this research ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Yale researchers discovered that an underactive mTOR pathway drives structural malformations in lissencephaly. Using patient-derived brain organoids, they showed that activating the mTOR pathway ...

New Haven, Conn. — Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and ...

Lissencephaly and subcortical band heterotopia are closely related cortical malformations and are true disorders of neuronal migration. The genetic basis of approximately 70% of classic ...

What Is the Significance of the Different Anteroposterior Patterns of Malformation Severity in Classic Lissencephaly? Spectrum of lissencephaly severity caused by LIS1 deletions or mutations.