As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including infertility, impaired immune function, decreased insulin response and altered homeostasis).

Results from high-fat diet mice showed that overexpression of gastric leptin that is linked to gut ‘5HT pathway’ occurred before the onset of obesity and expansion of fat mass. This may be ...

Because of these effects, it has been considered a plausible mechanism in the pathway leading from obesity to Alzheimer's disease. It is supported by findings tying higher leptin levels to lower ...

Multipurpose Hormone Scientists at Baylor College of Medicine have identified a new role for leptin: potent inhibitor of bone formation acting through the central nervous system (P. Ducy et al., ...

The present study is the first to show links between leptin and both amyloid and tau in humans using longitudinal and cross-sectional approaches, Lee and co-authors noted. The mechanistic pathway ...