脂多糖（LPS）是革兰氏阴性菌外膜的糖脂成分，像大肠杆菌这类革兰氏阴性菌表面的 LPS，能与人体免疫系统中单核细胞、巨噬细胞、树突状细胞和 B 细胞的 CD14/TLR4/MD2 受体结合，激活先天免疫，引发细胞因子风暴，进而导致内毒素血症和多器官衰竭。长期低水平 ...

Furthermore, liver, but not whole-body, insulin resistance was detected in LPS-infused mice. CD14 mutant mice resisted most of the LPS and high-fat diet-induced features of metabolic diseases.

LPS receptor-deleted mice (i.e., CD14 mutants) are hypersensitive to insulin, and the occurrence of insulin resistance, obesity, and diabetes is delayed in response to high-fat feeding.