These ADCs also use a proprietary payload system, based on a kinesin spindle protein inhibitor (KSPi). KSP is essential for mitosis, so when administered systemically, small-molecule KSPis are ...

Kinesin spindle protein inhibitors are novel agents and have shown promise in preclinical trials. SB-715992 is the first member of this class to be used in clinical trials. As a single agent in ...

During anaphase, the central region of the microtubule spindle reorganizes to produce ... a non-motor microtubule-associated protein (MAP)) and a kinesin-4 motor — comprise a minimal module ...

We are working to understanding how the mitotic spindle organizes and moves chromosomes. Recent projects have focused on the contributions of kinesin-8 motor proteins to chromosome movements, and ...