The type I interferon (IFN) system constitutes a highly redundant ... ligands Type I IFNs regulate both innate and adaptive immune responses, and can activate cells and effector pathways of ...

On the 50th anniversary of the discovery of interferon (IFN), we offer a perspective ... IFNs as a fundamental component of the innate immune system. Additionally, studies have revealed how ...

Recent advances in immunotherapy research have revealed crucial roles for new immune cells in combating cancer, leading to ...

But many of the tactics the virus and the immune system use in this contest have remained a mystery, making it challenging to design medicines to help patients defeat the virus. Interferons ...

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, with a survival rate of just 11%. A primary culprit ...

Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.

A treatment for hepatitis C is the drug interferon-alpha which challenges the immune system in the same way as a powerful infection. The team measured fatigue and immune markers before ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.