1). Indole carboxamide efflux pump inhibitors (EPIs) represent a new drug class designed to restore the efficacy of existing antibiotics against MDR Gram-negative bacteria. TAXIS’ EPIs have been ...

However, the precise mechanisms linking gut bacteria to arthritis remain unclear. A Key Discovery: Tryptophan Breakdown and Indole A groundbreaking study from the University of Colorado sheds ...

the researchers demonstrated that fiber-degrading gut bacteria, such as B. thetaiotaomicron, regulate the indole-forming activity of E. coli. "B. thetaiotaomicron assists by breaking down fibers ...

The production of interleukin (IL)-22 from host cells promotes gut barrier integrity, and bacterial products such as metabolites and flagellin induce host IL-22. In an article published in Cell ...