Functionally, there are two categories of IL-13 receptors: shared and private. IL13RA1 and IL4R make up the common IL-13 receptor. Additionally, IL-13 may bind to the exclusive IL-13 receptor IL13RA2.

We found that interleukin 4 receptor (IL-4R) knockout and downstream ... mice resisted tumor recurrence, which implicated IL-13, the only other cytokine that uses the IL-4R–STAT6 pathway.

Verekitug and Tezepelumab target TSLP receptor and TSLP ligand, respectively, while Dupilumab inhibits IL-4 and IL-13 receptors. Mepolizumab, on the other hand, targets IL-5. Regarding dosing ...