研究旨在对尼日利亚的恩达马牛（N’Dama）、穆图鲁牛（Muturu）和白富拉尼牛（White Fulani）的 IRF3 基因进行遗传特征分析。研究人员利用 Zymo - spin 提取试剂盒从血液样本中提取 DNA，借助 ARLEQUIN 2.0001 软件估算基础群体遗传统计数据，使用 DnaSP 5.10.01 版本软件评估 ...

Indeed, recent evidence showing that double-stranded DNA stimulates innate immune cells to produce type I interferons (IFNs) in a TBK1- and IRF3 (interferon-regulatory factor 3)-dependent manner ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

and mitochondria (mitochondrial DNA). A conserved molecular pathway controlled by the proteins cGAS, STING and IRF3 can detect DNA outside of these compartments, and report it to the neighboring ...

So, he focused on the chain of events upstream of STING. He obliterated STING in a murine cell line and transfected the cells with different types of DNA. The team then collected the cytoplasm and ...

DNA outside of these compartments can be detected by a conserved molecular pathway regulated by the proteins cGAS, STING, and IRF3. Secondary messengers, such as cGAMP and Interferon, can then ...