These mutations are essentially unique to gliomas ... Of the several forms, only IDH1 and IDH2 use NADP as a cofactor; the others use NAD. IDH1 is found in the cytoplasm and peroxisomes, whereas ...

Mutation testing could play a role in developing ... evaluated in a clinical trial that paired a JAK2 inhibitor with an IDH2 ...

After two decades of limited advancements, a new and promising breakthrough has emerged in the fight against glioma: ...