Although two independent domains of REST are known to confer repression, the mechanisms of transcriptional ... by recruiting the corepressor Sin3A and histone deacetylase (HDAC) to the promoter ...

Nevertheless, this study shows that targeting fungal histone acetylation using nicotinamide — which is well tolerated in humans — or future fungal sirtuin inhibitors is a novel strategy to ...

The histone chaperone Facilitates Chromatin Transcription (FACT) can clear macroH2A from specific locations on the chromatin, thereby activating gene transcription. However, the core mechanism by ...