这篇研究聚焦人乳头瘤病毒（HPV）相关宫颈癌。发现视网膜母细胞瘤蛋白（pRB）不仅是 HPV E7 的降解靶点，还对 E7 蛋白稳定至关重要。pRB 缺失会降低 E7 水平，抑制癌细胞增殖，为 HPV 相关癌症研究提供新思路。

The E6 and E7 proteins are implicated in the transformation ... 1-3 and adenocarcinoma in situ (AIS) associated with HPV 16 and 18. In the FUTURE I intention-to-treat group, which included women ...

由HPV16/18 E7蛋白检测卡、样本采集保存管 ... 组成。临床上用于HPV感染的初步筛查。 由滴管、比色卡、染色液（含乙酸、乙酸钠、磷钨酸、氯化 ...

Gen-Probe is currently developing the APTIMA HPV Assay, targeting E6/E7 mRNA from 14 carcinogenic HPV genotypes. A prototype of this assay was evaluated recently in 536 women with histological ...

The phase III, randomized, controlled Papilloma Trial Against Cancer in Young Adults (PATRICIA) showed that the HPV-16/18 vaccine has enhanced immunogenicity when aluminium hydroxide and ...

The E6 and E7 proteins are key oncogenes in the development of HPV-associated tumors ... Median age was 32.5 years, and 12 of 18 patients had a single HPV16 infection at baseline.