慢性 GVHD 中,巨噬细胞则倾向于 M2 表型,虽然 M2 巨噬细胞有助于组织修复,但也可能促进纤维化,导致器官功能障碍。比如,M2 巨噬细胞与 CD4 + 细胞和成纤维细胞的相互作用,会促进慢性 GVHD(cGVHD)中的组织纤维化 。 巨噬细胞还与其他免疫细胞相互作用 ...
Using a xenogeneic model of GvHD in NOD/SCID/γc− (NSG ... FITC anti-mouse CD45, FITC anti-human CD4, FITC anti-human CD14, PE anti-mouse CD45, PE anti-human CD8, PE anti-human CD19, PE anti ...
Whereas prior acute GVHD impaired Treg reconstitution, Treg subsets (absolute numbers and frequencies relative to CD4 + T-cell subsets) at 3, 6 and 12 months after HSCT were not associated with ...