为解决磷酸化和 O-GlcNAc 糖基化如何影响 RNA 聚合酶 II（RNA Pol II）相关蛋白复合物组装及 mRNA 成熟的问题，研究人员开展了关于动态 O-GlcNAc 糖基化 和磷酸化对 RNA Pol II 驱动转录影响的研究。结果发现二者对转录有重要调节作用，这为理解转录调控机制提供了新 ...

The reversible attachment of an activated form of N-acetylglucosamine (UDP-GlcNAc) acts as a molecular switch between the growth and arrest of cells, establishing a new role for cell surface glycans.

Importantly, activity assays determined that GnT-IVa enzyme with GlcNAc glycan branches (higher binding) near the lectin domain decreases the activity of modified GnT-IVa toward glycoprotein ...