其中，Cre-loxP 系统（一种用于在生物体内实现条件基因重组的强大工具）备受瞩目。它能让研究者根据 loxP 序列的方向，对生物基因组中特定 DNA 位点（floxed site）进行删除、倒置或易位操作 ，进而深入研究遗传、发育、生理和疾病等过程中的分子和细胞机制。

The Irf8 floxed mouse strain can be used to selectively ablate expression of IRF8 in any cell type in which a Cre recombinase gene is activated. This will permit the identification of IRF8 ...

Patients call it being 'floxed'. Yet despite patients going public with similar experiences, physicians are still prescribing the drug to at least 2million people every year. Looking back ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...