The extracellular matrix is a complex network of material such as proteins and polysaccharides that are secreted locally by cells and remain closely associated with them to provide structural ...

Before arriving at Janelia three years ago, Postdoctoral Scientist Antonio Fiore was designing and building optical instruments like microscopes and spectrometers. Fiore, a physicist by training, came ...

New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses ...

They saw that extracellular matrix fibres at the outer edges of tumours pointed away from the malignancy, providing a “track” for the cancer to follow to spread. In addition, the tumour cells in that ...

So far, Fiore's new direction is paying off. The extracellular matrix supports and gives structure to our cells and tissues: It provides a scaffold for cells to grow in, dictates the mechanical ...

Scientists find a way to predict which malignant tumours will become aggressive and metastasise to other parts of the body.

Intercellular adhesion can be mediated by adherens junctions, tight junctions and desmosomes, whereas cells can interact with extracellular matrix molecules through focal adhesions. Stem cell ...

Scientists have developed Rhobo6, a light microscopy probe that reveals extracellular matrix structures in live tissues, advancing biological research and disease diagnostics. Rhobo6 is a light ...

Tweaking the spacing between binding domains on the ECM surrounding cancer cells can boost their killing via ultrasound ...

New Zealand-based soft-tissue regeneration company Aroa Biosurgery has hit a key milestone with seven million of its products ...

A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy ...

"Our findings suggest that senescent cells maintain their large size through improved adhesion to the extracellular matrix ...